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Kisspeptin dosage: 1-5 mcg/kg subcutaneous pulsatile every 90-120 minutes. IVF trigger 6.4 nmol/kg single dose. Beginners start 1 mcg/kg, progress to 2-5 mcg/kg based on LH response. Weight-based dosing ensures equivalent hormone response across all body weights.
Optimal Kisspeptin Dosage Framework
Optimal kisspeptin dosage is weight-based: 1-5 mcg/kg per pulsatile injection every 90-120 minutes. For a 70 kg person: 70-350 mcg range, typically starting 70 mcg and titrating to 140-210 mcg. IVF protocols differ significantly: single 6.4 nmol/kg trigger dose (approximately 3-5 mcg/kg equivalent) administered 34-36 hours before egg retrieval. Weight-based dosing is critical because kisspeptin's pharmacokinetics require body weight adjustment for equivalent bioavailability and hormone response across different individuals.
Beginner Dosing Protocols
Week 1: Start conservatively at 1 mcg/kg every 2 hours. For 70 kg person = 70 mcg per injection, 4-5 injections daily. This allows tolerance assessment and minimizes overstimulation. Monitor for headache, flushing, or excessive LH elevation. Week 2-3: Progress to 1-2 mcg/kg every 90-120 minutes (6-7 injections daily) once tolerance confirmed. Week 4+: Titrate upward to therapeutic range (2-3 mcg/kg every 90-120 minutes) based on LH bloodwork and reproductive response.
Intermediate Dosing Progression
As tolerance develops and reproductive axis responds, increase dose by 0.5-1 mcg/kg every 3-5 days until reaching target hormone levels. Intermediate users typically stabilize at 2-3 mcg/kg every 90-120 minutes (7-8 injections daily across 12 hours). This produces robust LH elevation (5-10x baseline) without overstimulation. Adjust frequency based on convenience and response; some users prefer 120-minute spacing (6 injections daily), others use 90-minute intervals (8 injections daily).
Advanced Optimization Dosing
Experienced users may progress to 3-5 mcg/kg every 90-120 minutes for maximum reproductive stimulation. This requires careful hormone monitoring to confirm LH elevation without excessive overstimulation (>15x baseline). Higher doses suited for: male users seeking maximum testosterone elevation, women pursuing aggressive follicle recruitment for IVF, and individuals with severe baseline reproductive dysfunction requiring supraphysiologic stimulation. Advanced dosing requires bloodwork confirmation and careful symptom monitoring.
Weight-Based Dose Calculations
Formula: Dose (mcg) = mcg/kg rate × bodyweight (kg). Examples: 60 kg woman, 2 mcg/kg = 120 mcg per injection. 100 kg man, 3 mcg/kg = 300 mcg per injection. 50 kg lighter user, 2 mcg/kg = 100 mcg per injection. Weight-adjustment is essential; fixed doses ignore body composition variation and produce inconsistent results. Recalculate dosing every 4 weeks if weight changes >5 kg during treatment. Higher-weight individuals require proportionally more peptide for equivalent hormone response.
Female-Specific Dosing Protocols
Women pursuing menstrual restoration or fertility: 1-3 mcg/kg pulsatile every 90-120 minutes typical therapeutic range. IVF trigger protocol: 6.4 nmol/kg single dose 34-36 hours before retrieval. Follicle-responsive women may achieve ovulation at lower doses (1-2 mcg/kg); ovarian-resistant cases may require 3-5 mcg/kg. Dose titration based on ultrasound-confirmed follicle size and FSH response. Most women see ovulation within 4-6 weeks at therapeutic doses.
Male-Specific Dosing Protocols
Men targeting testosterone optimization and sperm improvement: 1-3 mcg/kg pulsatile every 90-120 minutes. Testosterone response appears within 1-2 weeks; sperm parameter improvements require 8-12 weeks of consistent dosing through complete spermatogenesis cycle. Some men respond optimally at 1-2 mcg/kg; others require 3-5 mcg/kg for maximum testosterone elevation. Dose titration guided by testosterone levels (target 500-900 ng/dL for young males) and semen analysis changes.
IVF Trigger Dosing Specifications
IVF kisspeptin trigger: 6.4 nmol/kg single subcutaneous injection 34-36 hours before egg retrieval. For 60 kg woman = ~384 nmol or 3-4 mcg/kg equivalent. For 70 kg woman = ~448 nmol or 4-5 mcg/kg equivalent. Timing critical: too early (>36 hours before retrieval) risks premature ovulation; too late (<34 hours) may leave oocytes incompletely mature. This single-dose approach replaces or supplements hCG as final maturation trigger.
Adjusting Dose Based on LH Response
Target LH response: baseline doubles to 10x within 30 minutes of injection. If LH <2x baseline: increase dose by 0.5-1 mcg/kg, retest after 3-4 days. If LH 3-10x: dose appropriate, maintain current level. If LH >15x: reduce dose slightly to prevent overstimulation. Monthly LH testing during titration phase ensures therapeutic range. Some individuals naturally respond robustly at lower doses (2x LH at 1 mcg/kg); others need higher doses (2x LH at 3 mcg/kg). Individual variation exists and drives personalized dose optimization.
Troubleshooting Non-Response and Adjustment
If no LH response after multiple injections: confirm injection technique (subcutaneous, not intramuscular), verify reconstitution quality, check refrigeration temperature, assess storage protection from light. Correct any identified issues. If technique correct but response absent: increase dose by 1 mcg/kg and retest LH. If persistent non-response despite dose escalation: consider peptide quality issues or rare cases of GnRH receptor dysfunction requiring medical evaluation.
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What's the standard starting dose for kisspeptin?
1 mcg/kg every 2 hours. For 70 kg person = 70 mcg per injection, 4-5 injections daily. Conservative starting dose allows tolerance assessment before titrating upward.
Can I take a fixed dose regardless of body weight?
Not recommended. Weight-based dosing ensures equivalent pharmacokinetics and hormone response. Fixed dosing causes heavy individuals to underdose (insufficient response) and light individuals to overdose (excessive stimulation). Weight adjustment is evidence-based.
How often should I increase my dose?
Increase by 0.5-1 mcg/kg every 3-5 days until reaching therapeutic LH elevation. Most reach optimal dose by week 2-3. Slower titration reduces overstimulation risk; faster titration reaches therapeutic levels sooner.
What if my dose seems too high?
If excessive headache or overstimulation symptoms appear, reduce dose by 0.5-1 mcg/kg. Retest LH after 3 days at lower dose. Most minor side effects resolve with dose reduction without sacrificing efficacy.
Is there a maximum safe dose?
Research tested up to 5 mcg/kg without serious adverse effects. Excessive dosing (>5 mcg/kg) causes overstimulation symptoms but no documented toxicity. Conservative titration to 2-3 mcg/kg is standard practice for most users.
Should I adjust dose if weight changes during treatment?
Yes. Recalculate every 4 weeks if weight changes >5 kg. Bodyweight reductions require dose reduction to maintain equivalent hormone response. Weight gain requires dose increase to prevent underdosing.