Peptide Half-Life Calculator

Choose a common compound or enter your own half-life. The tool plots an exponential decay curve over five half-lives and shows how long it takes to fall to 50%, 25%, 10% and 5% of the starting amount, plus a note on steady-state accumulation for repeat dosing.

Educational tool โ€” not medical advice. Half-life figures are approximate literature/community values for general reference and vary by source, individual physiology and assay. This tool only models exponential decay from the number you select or enter; it does not recommend any dose, compound, schedule or protocol. The peptides referenced are research chemicals not approved for human use by the FDA or any major regulator. Always consult a licensed healthcare professional. See our full disclaimer.

Time since dose % of dose remaining
50% remaining
โ€”
one half-life
25% remaining
โ€”
two half-lives
10% remaining
โ€”
~3.32 half-lives
5% remaining
โ€”
~4.32 half-lives
~Cleared (<1%)
โ€”
~6.6 half-lives
๐Ÿ“ˆ Steady-state accumulation

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How exponential decay works

A half-life is the time for the amount of a substance in circulation to fall by half. Because each half-life removes the same fraction (not the same amount), the decline follows an exponential curve โ€” fast at first, then ever slower.

Fraction remaining = (1/2) ^ (t รท half-life)
Time to reach fraction f = half-life ร— logโ‚‚(1 รท f)

That is why the milestones land where they do: 50% after 1 half-life, 25% after 2, about 10% after 3.32, about 5% after 4.32, and under 1% after roughly 6.6 half-lives โ€” the point most pharmacology references treat as functionally cleared.

Steady-state accumulation factor = 1 รท (1 โˆ’ (1/2)^(interval รท half-life))

Repeated dosing. If a compound is re-dosed before it fully clears, levels build up until the amount cleared each interval equals the amount added. The shorter the interval relative to the half-life, the higher this plateau. The accumulation factor above estimates the trough multiple versus a single dose, and it generally takes about five half-lives to approach that steady state.

Reference half-lives used by this tool

Approximate values for general reference only; sources and individuals vary. Many peptides have a short circulating half-life yet far longer tissue or biological effects โ€” see each compound's full guide for nuance.

CompoundApprox. half-life (this tool)Note

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