5-Amino-1MQ is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
5-Amino-1MQ (5-Amino-1-Methyl-Quinolinium) is a Small molecule NNMT inhibitor. Synthetic compound designed to inhibit nicotinamide N-methyltransferase (NNMT) and boost NAD+ synthesis through the salvage pathway. It is researched for fat oxidation, metabolic flexibility, improved grip strength, increased endurance, reduced muscle recovery time, anti-aging effects. Common dosages range from 150-500 mcg subcutaneous, 50-100 mg oral administered once to twice daily.
What Is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-Methyl-Quinolinium) is a Small molecule NNMT inhibitor. Synthetic compound designed to inhibit nicotinamide N-methyltransferase (NNMT) and boost NAD+ synthesis through the salvage pathway. Also known as 5A1MQ, 5-amino-1MQ, it has been studied for its potential effects on fat oxidation, metabolic flexibility, improved grip strength, increased endurance, reduced muscle recovery time, anti-aging effects.
First-in-class NNMT inhibitor — the only compound that boosts NAD+ by preventing its precursor from being degraded, rather than simply supplementing more precursor. In the research community, 5-Amino-1MQ has gained attention for its distinctive profile.
How Does 5-Amino-1MQ Work?
Selectively inhibits the NNMT enzyme, which normally degrades nicotinamide and prevents NAD+ synthesis. By blocking NNMT, it frees nicotinamide for NAD+ production via the salvage pathway and activates SIRT1 longevity pathways. Also stimulates AMP-activated protein kinase (AMPK) in adipocytes and myocytes, promoting mitochondrial biogenesis and fat oxidation.
This multi-pathway activity helps explain why 5-Amino-1MQ shows potential across several different applications.
What Does the Research Say About 5-Amino-1MQ?
Improved grip strength by ~60% when combined with exercise in aged mice. Increased endurance and reduced recovery time in animal models. Preclinical evidence shows protection against diet-induced weight gain. No human clinical trials completed.
Researchers should consult the latest peer-reviewed literature for the most current findings.
What Is the Recommended 5-Amino-1MQ Dosage?
Standard 5-Amino-1MQ dosing: 150-500 mcg subcutaneous, 50-100 mg oral, administered once to twice daily via subcutaneous injection or oral.
Half-life: not established in humans. Cycle length: 4-12 weeks.
Use our peptide dosing calculator for exact reconstitution ratios.
Calculate Your 5-Amino-1MQ Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for 5-Amino-1MQ.
Open Calculator →What Are the Side Effects of 5-Amino-1MQ?
Good tolerability in preclinical data. No major adverse events reported. Limited human safety data — long-term effects in humans unknown.
5-Amino-1MQ is not fda-approved. available as research chemical. not scheduled or controlled.
Can You Stack 5-Amino-1MQ With Other Peptides?
Pairs well with NAD+ precursors (NMN, NR) for synergistic metabolic enhancement, and with MOTS-C for comprehensive mitochondrial optimization.
What Is the Bottom Line on 5-Amino-1MQ?
5-Amino-1MQ is a Small molecule NNMT inhibitor researched for fat oxidation, metabolic flexibility, improved grip strength, increased endurance, reduced muscle recovery time, anti-aging effects. Standard protocols use 150-500 mcg subcutaneous, 50-100 mg oral once to twice daily for 4-12 weeks.
Source from COA-tested vendors. Read our beginner's guide for more, or use the dosing calculator to plan your protocol.
Complete Guide
5-Amino-1MQ : Benefits, Dosage, Side Effects & Research
Related Reading
- 5-Amino-1MQ Dosage Guide
- 5-Amino-1MQ Benefits
- 5-Amino-1MQ Side Effects
- 5-Amino-1MQ Stacking Guide
- 5-Amino-1MQ Cycle Guide
- 5-Amino-1MQ Research
Research-Grade Sourcing
If you're going to research 5-Amino-1MQ, source matters. These are the suppliers WolveStack has vetted for purity and third-party testing.
Frequently Asked Questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-Methyl-Quinolinium) is a Small molecule NNMT inhibitor. Synthetic compound designed to inhibit nicotinamide N-methyltransferase (NNMT) and boost NAD+ synthesis through the salvage pathway. It is researched for fat oxidation, metabolic flexibility, improved grip strength, increased endurance, reduced muscle recovery time, anti-aging effects.
What is the recommended 5-Amino-1MQ dosage?
Common dosages: 150-500 mcg subcutaneous, 50-100 mg oral administered once to twice daily via subcutaneous injection or oral. Cycle length: 4-12 weeks. Half-life: not established in humans. Use our peptide calculator for exact reconstitution math.
What are the side effects of 5-Amino-1MQ?
Good tolerability in preclinical data. No major adverse events reported. Limited human safety data — long-term effects in humans unknown.
Is 5-Amino-1MQ safe?
5-Amino-1MQ has shown a preliminary safety profile in research. Not FDA-approved. Available as research chemical. Not scheduled or controlled. All research should follow appropriate safety protocols.