VIP is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
The most common research dosage for VIP is 50-100 mcg per spray or 200 mcg daily inhaled, administered 4 times daily (nasal) or daily (inhaled) via intranasal spray or inhalation. Typical cycles run ongoing continuous therapy. With a half-life of 2 minutes (extremely short), timing matters for optimal results.
What Is VIP and Why Does Dosing Matter?
VIP (Vasoactive Intestinal Peptide) is a Neuropeptide, vasodilator, anti-inflammatory. Endogenous 28-amino acid neuropeptide produced in gut, pancreas, brain, and neuroendocrine tissues. Getting the dosage right is critical — too little may produce no measurable effect, while excessive amounts increase risk without proportional benefit.
The standard research dosage for VIP has been established through preclinical studies and community protocols. This guide covers the evidence-backed dosing range, timing, and cycle structure.
What Is the Recommended VIP Dosage?
The most widely used VIP dosage is 50-100 mcg per spray or 200 mcg daily inhaled, administered 4 times daily (nasal) or daily (inhaled) via intranasal spray or inhalation.
Beginners should start at the lower end of this range and titrate upward only if needed. The half-life of VIP is 2 minutes (extremely short), which directly determines how often you need to dose to maintain stable blood levels.
For VIP specifically, the ongoing continuous therapy cycle length is standard. Longer isn't always better — Neuropeptide, vasodilator, anti-inflammatory compounds require cycling to maintain receptor sensitivity.
When Should You Dose VIP?
With a half-life of 2 minutes (extremely short), timing your VIP administration affects peak blood levels. Most protocols call for 4 times daily (nasal) or daily (inhaled).
For peptides administered before bed (common with GH-related compounds), the goal is to amplify the natural nocturnal growth hormone pulse. For healing peptides, proximity to the injury site via local injection can improve outcomes.
Calculate Your VIP Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for VIP.
Open Calculator →How Do You Reconstitute VIP?
VIP typically comes as a lyophilized (freeze-dried) powder. Reconstitute with bacteriostatic water — never saline or sterile water, as BAC water contains 0.9% benzyl alcohol that prevents bacterial growth and extends shelf life to 4-6 weeks.
Use our peptide dosing calculator to determine the exact amount of BAC water to add based on your vial size and desired dose per injection.
How Long Should a VIP Cycle Last?
Standard VIP cycles run ongoing continuous therapy. This timeframe is based on the compound's mechanism and the time needed to observe measurable effects.
Phase 3 TESICO trial (471 patients with COVID-19) halted for futility with IV dosing. Phase 2 RCT (80 subjects, inhaled) showed positive signal. Orphan drug designation for pulmonary hypertension. Limited human data; research ongoing.
What Side Effects Can Affect Dosing?
Limited clinical data. Nasal irritation possible. Short half-life limits systemic toxicity. Well-tolerated in preliminary studies.
If side effects emerge, the first step is typically reducing the dose rather than discontinuing entirely. Most VIP-related side effects are dose-dependent.
How Does VIP Dosing Change When Stacking?
Combines with inhaled corticosteroids or bronchodilators for synergistic airway relaxation in asthma/COPD.
When stacking, some researchers reduce individual peptide doses by 20-30% since synergistic effects mean full doses of each aren't always necessary.
What Is the Bottom Line on VIP Dosing?
Start at 50, dose 4 times daily (nasal) or daily (inhaled), and run cycles of ongoing continuous therapy. Monitor your response and adjust within the established range.
Source matters — always use research-grade VIP from vendors with third-party COA testing. Underdosed or contaminated products are the most common reason for poor results.
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Research-Grade Sourcing
If you're going to research VIP, source matters. These are the suppliers WolveStack has vetted for purity and third-party testing.
Frequently Asked Questions
What is VIP?
VIP (Vasoactive Intestinal Peptide) is a Neuropeptide, vasodilator, anti-inflammatory. Endogenous 28-amino acid neuropeptide produced in gut, pancreas, brain, and neuroendocrine tissues. It is researched for vasodilation, bronchodilation, anti-inflammatory effects, neuroprotection, lung function improvement.
What is the recommended VIP dosage?
Common dosages: 50-100 mcg per spray or 200 mcg daily inhaled administered 4 times daily (nasal) or daily (inhaled) via intranasal spray or inhalation. Cycle length: ongoing continuous therapy. Half-life: 2 minutes (extremely short). Use our peptide calculator for exact reconstitution math.
What are the side effects of VIP?
Limited clinical data. Nasal irritation possible. Short half-life limits systemic toxicity. Well-tolerated in preliminary studies.
Is VIP safe?
VIP has shown a favorable safety profile in research. Not FDA-approved. Orphan drug designation for pulmonary hypertension. FDA announced plans to remove from compounding lists. All research should follow appropriate safety protocols.