Semax is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
Semax (Synthetic ACTH(4-10) analog heptapeptide) is a Neuropeptide, nootropic, ACTH analog. Developed by Russian scientists in the 1980s as a synthetic ACTH fragment analog for neuroprotection in stroke and cognitive decline. It is researched for BDNF elevation, neuroprotection, cognitive enhancement, stroke recovery, memory consolidation. Common dosages range from 200-600 mcg daily administered 2-4 times daily.
What Is Semax?
Semax (Synthetic ACTH(4-10) analog heptapeptide) is a Neuropeptide, nootropic, ACTH analog. Developed by Russian scientists in the 1980s as a synthetic ACTH fragment analog for neuroprotection in stroke and cognitive decline. Also known as Semax, Met-Glu-His-Phe-Pro-Gly-Pro, it has been studied for its potential effects on BDNF elevation, neuroprotection, cognitive enhancement, stroke recovery, memory consolidation.
Most extensively clinically used ACTH analog with 40+ years of Russian track record — uniquely bridges neuroprotection (BDNF) with ACTH-independent mechanisms, avoiding the HPA-axis suppression of the parent hormone. In the research community, Semax has gained attention for its distinctive profile.
How Does Semax Work?
Antagonizes α-MSH at MC4/MC5 receptors while inhibiting enkephalin-degrading enzymes to elevate endogenous opioid peptides. Dramatically upregulates BDNF protein for neuronal survival and synaptogenesis. Modulates dopaminergic and serotonergic systems for neuroprotection and cognitive enhancement.
This multi-pathway activity helps explain why Semax shows potential across several different applications.
What Does the Research Say About Semax?
Russian clinical protocols document efficacy for stroke, ischemic injury, and cognitive impairment over 30+ years. Genome-wide transcriptional analysis shows effects on vascular and immune genes. On Russia's List of Vital and Essential Drugs.
Researchers should consult the latest peer-reviewed literature for the most current findings.
What Is the Recommended Semax Dosage?
Standard Semax dosing: 200-600 mcg daily, administered 2-4 times daily via intranasal spray.
Half-life: not established. Cycle length: 5-14 days; repeated cycles with washout.
Use our peptide dosing calculator for exact reconstitution ratios.
Calculate Your Semax Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for Semax.
Open Calculator →What Are the Side Effects of Semax?
Nasal irritation (dryness, burning). Nasal cavity discoloration in ~10% of users. Possible increased blood glucose in diabetics. Overall mild adverse effects.
Semax is not fda-approved. licensed pharmaceutical in russia. available as research chemical in us.
Can You Stack Semax With Other Peptides?
Synergizes with Selank — Semax drives BDNF/neuroprotection while Selank provides GABAergic anxiolysis, covering complementary cognitive pathways.
What Is the Bottom Line on Semax?
Semax is a Neuropeptide, nootropic, ACTH analog researched for BDNF elevation, neuroprotection, cognitive enhancement, stroke recovery, memory consolidation. Standard protocols use 200-600 mcg daily 2-4 times daily for 5-14 days; repeated cycles with washout.
Source from COA-tested vendors. Read our beginner's guide for more, or use the dosing calculator to plan your protocol.
Complete Guide
Semax: The Russian Nootropic Peptide
Related Reading
- Semax Dosage Guide
- Semax Benefits
- Semax Side Effects
- Semax Stacking Guide
- Semax Cycle Guide
- Semax Research
Research-Grade Sourcing
If you're going to research Semax, source matters. These are the suppliers WolveStack has vetted for purity and third-party testing.
Frequently Asked Questions
What is Semax?
Semax (Synthetic ACTH(4-10) analog heptapeptide) is a Neuropeptide, nootropic, ACTH analog. Developed by Russian scientists in the 1980s as a synthetic ACTH fragment analog for neuroprotection in stroke and cognitive decline. It is researched for BDNF elevation, neuroprotection, cognitive enhancement, stroke recovery, memory consolidation.
What is the recommended Semax dosage?
Common dosages: 200-600 mcg daily administered 2-4 times daily via intranasal spray. Cycle length: 5-14 days; repeated cycles with washout. Half-life: not established. Use our peptide calculator for exact reconstitution math.
What are the side effects of Semax?
Nasal irritation (dryness, burning). Nasal cavity discoloration in ~10% of users. Possible increased blood glucose in diabetics. Overall mild adverse effects.
Is Semax safe?
Semax has shown a preliminary safety profile in research. Not FDA-approved. Licensed pharmaceutical in Russia. Available as research chemical in US. All research should follow appropriate safety protocols.