Melanotan I is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
Melanotan I (Afamelanotide) is a Melanocortin-1 receptor (MC1R) agonist researched for skin pigmentation, phototoxicity reduction in EPP patients, UV-free tanning. Common dosages range from 16 mg implant (FDA-approved); 0.025-0.3 mg/kg (research dosing) administered every 60 days (implant) or daily (injection). Below are the most frequently asked questions.
Frequently Asked Questions About Melanotan I
What is Melanotan I?
Melanotan I (Afamelanotide) is a Melanocortin-1 receptor (MC1R) agonist. Synthetic α-MSH analog developed to stimulate melanin production through selective MC1R activation. It is researched for skin pigmentation, phototoxicity reduction in EPP patients, UV-free tanning.
What is the recommended Melanotan I dosage?
Common dosages range from 16 mg implant (FDA-approved); 0.025-0.3 mg/kg (research dosing), administered every 60 days (implant) or daily (injection) via subcutaneous implant (approved) or subcutaneous injection. Cycles typically run 60-day implant cycles; 4-8 weeks injection cycles.
What are the side effects of Melanotan I?
Milder than Melanotan II: fatigue, headache, facial flushing, nausea, development or darkening of freckles/moles. Slower onset than MT-II (weeks vs days). Generally considered safer.
Is Melanotan I legal?
FDA-approved as Scenesse for EPP only (prescription). Not approved for cosmetic tanning.
What is the half-life of Melanotan I?
The half-life of Melanotan I is ~2 hours circulating; implant provides 2-month depot release, which determines the every 60 days (implant) or daily (injection) dosing schedule.
How do you reconstitute Melanotan I?
Add bacteriostatic water to the lyophilized Melanotan I vial. Let the water run down the side — never spray on the powder. Swirl gently. Use our peptide calculator for exact amounts.
Can you stack Melanotan I with other peptides?
Used as standalone; not typically combined with other melanocortin peptides.
Where can you buy Melanotan I?
Melanotan I is available as a research chemical from vetted suppliers with third-party COA testing.
How long does it take Melanotan I to work?
Initial effects may be noticed within 1-2 weeks, with more significant results typically appearing by weeks 4-8 of a 60-day implant cycles; 4-8 weeks injection cycles cycle.
What makes Melanotan I unique?
The only Melanotan analog with FDA approval and extensive Phase III clinical trial data — far better characterized for safety than the more popular (but more dangerous) Melanotan II.
Complete Guide
Melanotan I : Benefits, Dosage, Side Effects & Research
Related Reading
- Melanotan I Dosage Guide
- Melanotan I Benefits
- Melanotan I Side Effects
- Melanotan I Stacking Guide
- Melanotan I Cycle Guide
- Melanotan I Research
Calculate Your Melanotan I Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for Melanotan I.
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Frequently Asked Questions
What is Melanotan I?
Melanotan I (Afamelanotide) is a Melanocortin-1 receptor (MC1R) agonist. Synthetic α-MSH analog developed to stimulate melanin production through selective MC1R activation. It is researched for skin pigmentation, phototoxicity reduction in EPP patients, UV-free tanning.
What is the recommended Melanotan I dosage?
Common dosages: 16 mg implant (FDA-approved); 0.025-0.3 mg/kg (research dosing) administered every 60 days (implant) or daily (injection) via subcutaneous implant (approved) or subcutaneous injection. Cycle length: 60-day implant cycles; 4-8 weeks injection cycles. Half-life: ~2 hours circulating; implant provides 2-month depot release. Use our peptide calculator for exact reconstitution math.
What are the side effects of Melanotan I?
Milder than Melanotan II: fatigue, headache, facial flushing, nausea, development or darkening of freckles/moles. Slower onset than MT-II (weeks vs days). Generally considered safer.
Is Melanotan I safe?
Melanotan I has shown a preliminary safety profile in research. FDA-approved as Scenesse for EPP only (prescription). Not approved for cosmetic tanning. All research should follow appropriate safety protocols.