TB-500 is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
TB-500 (Thymosin Beta-4 Fragment (TB-500)) is a 43-amino acid peptide. Naturally occurring peptide present in virtually all human and animal cells. It is researched for wound healing, tissue repair, inflammation reduction, hair regrowth, cardiac repair, flexibility improvement. Common dosages range from 2-5 mg (loading), 2 mg (maintenance) administered 2x weekly (loading phase), weekly (maintenance).
What Is TB-500?
TB-500 (Thymosin Beta-4 Fragment (TB-500)) is a 43-amino acid peptide. Naturally occurring peptide present in virtually all human and animal cells. Also known as TB-500, Thymosin Beta 4, Tβ4, it has been studied for its potential effects on wound healing, tissue repair, inflammation reduction, hair regrowth, cardiac repair, flexibility improvement.
The only peptide present in virtually every cell of the human body, with a decades-long safety record in equine veterinary medicine providing real-world long-term data unavailable for most peptides. In the research community, TB-500 has gained attention for its distinctive profile.
How Does TB-500 Work?
TB-500 promotes cell migration by upregulating actin, a cell-building protein essential for cytoskeletal dynamics. It sequesters actin monomers to regulate polymerization, reduces inflammation by downregulating pro-inflammatory cytokines, and promotes angiogenesis and stem cell differentiation for tissue repair.
This multi-pathway activity helps explain why TB-500 shows potential across several different applications.
What Does the Research Say About TB-500?
Research shows TB-500 accelerates wound healing, promotes cardiac repair after injury, reduces inflammatory cytokines, and supports dermal healing. Used extensively in equine medicine for over two decades with strong safety record.
Researchers should consult the latest peer-reviewed literature for the most current findings.
What Is the Recommended TB-500 Dosage?
Standard TB-500 dosing: 2-5 mg (loading), 2 mg (maintenance), administered 2x weekly (loading phase), weekly (maintenance) via subcutaneous or intramuscular injection.
Half-life: approximately 2-3 hours. Cycle length: 4-6 weeks loading, then ongoing maintenance.
Use our peptide dosing calculator for exact reconstitution ratios.
Calculate Your TB-500 Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for TB-500.
Open Calculator →What Are the Side Effects of TB-500?
Generally well-tolerated. Temporary lethargy, head rush, or mild headache reported in some users. Minor injection site irritation possible. No organ toxicity documented in research.
TB-500 is not fda-approved. available as a research chemical. banned by wada in athletic competition.
Can You Stack TB-500 With Other Peptides?
Pairs powerfully with BPC-157 in the 'Wolverine Stack' — TB-500 handles systemic inflammation and cardiac repair while BPC-157 targets gut and connective tissue. Also stacks well with GHK-Cu for skin and wound healing.
What Is the Bottom Line on TB-500?
TB-500 is a 43-amino acid peptide researched for wound healing, tissue repair, inflammation reduction, hair regrowth, cardiac repair, flexibility improvement. Standard protocols use 2-5 mg (loading), 2 mg (maintenance) 2x weekly (loading phase), weekly (maintenance) for 4-6 weeks loading, then ongoing maintenance.
Source from COA-tested vendors. Read our beginner's guide for more, or use the dosing calculator to plan your protocol.
Complete Guide
TB-500 : Thymosin Beta-4, Research Evidence & Protocols
Related Reading
- TB-500 Dosage Guide
- TB-500 Benefits
- TB-500 Side Effects
- TB-500 Stacking Guide
- TB-500 Cycle Guide
- TB-500 Research
Research-Grade Sourcing
If you're going to research TB-500, source matters. These are the suppliers WolveStack has vetted for purity and third-party testing.
Frequently Asked Questions
What is TB-500?
TB-500 (Thymosin Beta-4 Fragment (TB-500)) is a 43-amino acid peptide. Naturally occurring peptide present in virtually all human and animal cells. It is researched for wound healing, tissue repair, inflammation reduction, hair regrowth, cardiac repair, flexibility improvement.
What is the recommended TB-500 dosage?
Common dosages: 2-5 mg (loading), 2 mg (maintenance) administered 2x weekly (loading phase), weekly (maintenance) via subcutaneous or intramuscular injection. Cycle length: 4-6 weeks loading, then ongoing maintenance. Half-life: approximately 2-3 hours. Use our peptide calculator for exact reconstitution math.
What are the side effects of TB-500?
Generally well-tolerated. Temporary lethargy, head rush, or mild headache reported in some users. Minor injection site irritation possible. No organ toxicity documented in research.
Is TB-500 safe?
TB-500 has shown a favorable safety profile in research. Not FDA-approved. Available as a research chemical. Banned by WADA in athletic competition. All research should follow appropriate safety protocols.