SSRIs and SNRIs are safe with semaglutide. No major drug interactions documented. Semaglutide may improve mood and reduce depression-associated eating, complementing antidepressant therapy. Monitor appetite/satiety effects; some antidepressants increase appetite (bupropion, mirtazapine) which may partially offset semaglutide weight loss.

Can You Take Antidepressants With Semaglutide?

SSRIs and SNRIs are safe with semaglutide. No major drug interactions documented. Semaglutide may improve mood and reduce depression-associated eating, complementing antidepressant therapy. Monitor appetite/satiety effects; some antidepressants increase appetite (bupropion, mirtazapine) which may partially offset semaglutide weight loss.

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