Melanotan II is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
Melanotan II (Melanotan II (cyclic α-MSH analog)) is a Non-selective melanocortin receptor agonist. Synthetic cyclic α-MSH analog with non-selective activity across MC1, MC3, MC4, and MC5 receptors. It is researched for rapid skin darkening, appetite suppression, erectile function enhancement, increased libido. Common dosages range from 250-500 mcg per injection administered every other day.
What Is Melanotan II?
Melanotan II (Melanotan II (cyclic α-MSH analog)) is a Non-selective melanocortin receptor agonist. Synthetic cyclic α-MSH analog with non-selective activity across MC1, MC3, MC4, and MC5 receptors. Also known as Melanotan II, MT-II, 'barbie drug', it has been studied for its potential effects on rapid skin darkening, appetite suppression, erectile function enhancement, increased libido.
The most popular underground tanning peptide due to rapid results, but also the most dangerous melanocortin peptide — non-selective receptor activation creates a cocktail of unpredictable systemic effects that has led to bans across multiple countries. In the research community, Melanotan II has gained attention for its distinctive profile.
How Does Melanotan II Work?
Non-selectively activates multiple melanocortin receptors simultaneously: MC1R drives melanin synthesis in skin, MC3R/MC4R affect appetite suppression and sexual function, MC5R modulates exocrine glands. This broad receptor activation produces rapid tanning but also unpredictable systemic effects including libido enhancement and appetite suppression.
This multi-pathway activity helps explain why Melanotan II shows potential across several different applications.
What Does the Research Say About Melanotan II?
Limited formal clinical trials. One pilot Phase I study documented tanning and sexual effects but raised significant safety concerns. Most evidence comes from case reports of serious adverse events. Banned in multiple countries.
Researchers should consult the latest peer-reviewed literature for the most current findings.
What Is the Recommended Melanotan II Dosage?
Standard Melanotan II dosing: 250-500 mcg per injection, administered every other day via subcutaneous injection.
Half-life: not precisely established; effects persist longer than MT-I. Cycle length: 2-4 weeks for tanning effects.
Use our peptide dosing calculator for exact reconstitution ratios.
Calculate Your Melanotan II Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for Melanotan II.
Open Calculator →What Are the Side Effects of Melanotan II?
Extensive adverse effects: nausea, vomiting, facial flushing, involuntary erections, yawning, loss of appetite. Serious reports of rhabdomyolysis, renal infarction, posterior reversible encephalopathy syndrome, and sympathomimetic toxicity. Increased melanoma risk, atypical moles, melanonychia (nail darkening). Dose-dependent toxicity.
Melanotan II is not fda-approved. banned for human use in many jurisdictions. warnings issued by us fda, uk mhra, and other health agencies. wada banned.
Can You Stack Melanotan II With Other Peptides?
Not recommended for stacking due to serious safety profile and non-selective receptor activation.
What Is the Bottom Line on Melanotan II?
Melanotan II is a Non-selective melanocortin receptor agonist researched for rapid skin darkening, appetite suppression, erectile function enhancement, increased libido. Standard protocols use 250-500 mcg per injection every other day for 2-4 weeks for tanning effects.
Source from COA-tested vendors. Read our beginner's guide for more, or use the dosing calculator to plan your protocol.
Complete Guide
Melanotan II: Research
Related Reading
- Melanotan II Dosage Guide
- Melanotan II Benefits
- Melanotan II Side Effects
- Melanotan II Stacking Guide
- Melanotan II Cycle Guide
- Melanotan II Research
Research-Grade Sourcing
If you're going to research Melanotan II, source matters. These are the suppliers WolveStack has vetted for purity and third-party testing.
Frequently Asked Questions
What is Melanotan II?
Melanotan II (Melanotan II (cyclic α-MSH analog)) is a Non-selective melanocortin receptor agonist. Synthetic cyclic α-MSH analog with non-selective activity across MC1, MC3, MC4, and MC5 receptors. It is researched for rapid skin darkening, appetite suppression, erectile function enhancement, increased libido.
What is the recommended Melanotan II dosage?
Common dosages: 250-500 mcg per injection administered every other day via subcutaneous injection. Cycle length: 2-4 weeks for tanning effects. Half-life: not precisely established; effects persist longer than MT-I. Use our peptide calculator for exact reconstitution math.
What are the side effects of Melanotan II?
Extensive adverse effects: nausea, vomiting, facial flushing, involuntary erections, yawning, loss of appetite. Serious reports of rhabdomyolysis, renal infarction, posterior reversible encephalopathy syndrome, and sympathomimetic toxicity. Increased melanoma risk, atypical moles, melanonychia (nail darkening). Dose-dependent toxicity.
Is Melanotan II safe?
Melanotan II has shown a preliminary safety profile in research. Not FDA-approved. Banned for human use in many jurisdictions. Warnings issued by US FDA, UK MHRA, and other health agencies. WADA banned. All research should follow appropriate safety protocols.