LL-37 is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
Lyophilized (freeze-dried) LL-37 should be stored at -20°C for long-term stability. Once reconstituted with bacteriostatic water, store at 2-8°C (refrigerated) and use within 4-6 weeks. Never freeze reconstituted peptides.
How Do You Store LL-37?
Proper storage is critical for maintaining LL-37's potency and safety. As a Antimicrobial peptide, host defense peptide, LL-37 is sensitive to heat, light, and moisture — improper storage can render it ineffective or harmful.
How Do You Store Lyophilized LL-37?
Unreconstituted (freeze-dried) LL-37: Store at -20°C (standard freezer) for maximum shelf life of 12-24+ months. Keep the vial sealed and away from moisture.
Room temperature storage is acceptable for short periods (shipping) but degrades potency over weeks. Refrigerator (2-8°C) storage extends this to several months.
How Do You Store Reconstituted LL-37?
After mixing with bacteriostatic water: Store at 2-8°C (standard refrigerator). Use within 4-6 weeks for optimal potency.
Never freeze reconstituted LL-37. Freezing and thawing damages the peptide structure. The bacteriostatic water's benzyl alcohol preservative is what allows the 4-6 week window — sterile water would give you only days.
Keep the vial upright and away from the refrigerator door (temperature fluctuations from opening/closing).
How Do You Know if LL-37 Has Gone Bad?
Reconstituted LL-37 should be clear and colorless. If you see cloudiness, particles, or discoloration — discard it. These indicate bacterial contamination or peptide degradation.
If stored properly, degradation is gradual and may not be visually apparent. This is why the 4-6 week window for reconstituted peptides exists.
Can You Travel With LL-37?
Lyophilized LL-37 can be shipped with cold packs and insulation. For short trips, a small cooler bag with an ice pack maintains adequate temperature.
Reconstituted LL-37 is more temperature-sensitive and should be kept refrigerated during travel if possible.
Bottom Line on LL-37 Storage
Freeze-dried: -20°C, sealed, 12+ months. Reconstituted: 2-8°C, use within 4-6 weeks, never freeze. Source from vendors who ship with proper cold-chain packaging.
Complete Guide
LL-37 : Benefits, Dosage, Side Effects & Research
Related Reading
- LL-37 Dosage Guide
- LL-37 Benefits
- LL-37 Side Effects
- LL-37 Stacking Guide
- LL-37 Cycle Guide
- LL-37 Research
Calculate Your LL-37 Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for LL-37.
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Frequently Asked Questions
What is LL-37?
LL-37 (Human cathelicidin antimicrobial peptide LL-37) is a Antimicrobial peptide, host defense peptide. Endogenous human antimicrobial peptide; the only human member of the cathelicidin family; produced by neutrophils, macrophages, and epithelial cells. It is researched for broad-spectrum antimicrobial activity, biofilm disruption, wound healing acceleration, immune enhancement.
What is the recommended LL-37 dosage?
Common dosages: 100-500 mcg (topical/local application) administered topical or local application as needed via topical wound application, local injection, intranasal. Cycle length: acute use as needed. Half-life: rapidly degraded by proteases; major clinical limitation. Use our peptide calculator for exact reconstitution math.
What are the side effects of LL-37?
Dose-dependent cytotoxicity to human cells above 75 mcg/mL. Hemolytic effects at high concentrations. Proteolytic degradation limits bioavailability. Potential immune overstimulation.
Is LL-37 safe?
LL-37 has shown a preliminary safety profile in research. Not FDA-approved as therapeutic. Research compound. Derivatives in late-stage clinical trials. All research should follow appropriate safety protocols.