AOD-9604 is a research compound. It is not approved by the FDA or any regulatory body for human use. This article is for educational and informational purposes only. Nothing here constitutes medical advice. Consult a qualified physician before considering any peptide use.
AOD-9604 (Fragment 177-191 of Human Growth Hormone (modified)) is a Lipolytic peptide, GH fragment analog. Synthetic analog of human GH fragment 177-191, engineered to selectively activate lipolysis without systemic GH effects. It is researched for fat loss, increased fat oxidation, improved body composition, joint health support, no IGF-1 elevation. Common dosages range from 250-1000 mcg daily administered once daily, ideally morning fasted.
What Is AOD-9604?
AOD-9604 (Fragment 177-191 of Human Growth Hormone (modified)) is a Lipolytic peptide, GH fragment analog. Synthetic analog of human GH fragment 177-191, engineered to selectively activate lipolysis without systemic GH effects. Also known as AOD 9604, Obenix, Lipotropin, it has been studied for its potential effects on fat loss, increased fat oxidation, improved body composition, joint health support, no IGF-1 elevation.
The only GH fragment that selectively targets fat loss without any of growth hormone's effects on blood sugar, insulin, or IGF-1 — making it metabolically clean. The catch is that human efficacy was modest compared to impressive animal data. In the research community, AOD-9604 has gained attention for its distinctive profile.
How Does AOD-9604 Work?
Activates beta-3 adrenergic receptors in adipose tissue, triggering cAMP-mediated lipolysis and release of stored fat for energy. Suppresses lipogenesis (new fat formation) while promoting fat breakdown. Unlike full growth hormone, it does not raise IGF-1 or impact glucose metabolism, blood sugar, or insulin sensitivity.
This multi-pathway activity helps explain why AOD-9604 shows potential across several different applications.
What Does the Research Say About AOD-9604?
12-week RCT showed 2.6 kg weight loss vs 0.8 kg placebo. However, a larger 24-week Phase III trial (536 subjects) failed to demonstrate significant weight loss, leading to development discontinuation in 2007. Six controlled trials established tolerability across 900+ subjects.
Researchers should consult the latest peer-reviewed literature for the most current findings.
What Is the Recommended AOD-9604 Dosage?
Standard AOD-9604 dosing: 250-1000 mcg daily, administered once daily, ideally morning fasted via subcutaneous injection.
Half-life: not established. Cycle length: 12-24 weeks.
Use our peptide dosing calculator for exact reconstitution ratios.
Calculate Your AOD-9604 Dose
Use our free peptide dosing calculator to get exact reconstitution math and syringe units for AOD-9604.
Open Calculator →What Are the Side Effects of AOD-9604?
Well-tolerated across 900+ participants in clinical trials. Minimal adverse effects — potential mild headache, dizziness, or injection site reactions. One of the safest peptides in terms of documented human tolerability.
AOD-9604 is not fda-approved. development discontinued 2007. available as research chemical.
Can You Stack AOD-9604 With Other Peptides?
Pairs with CJC-1295/Ipamorelin for enhanced body composition (AOD handles fat loss while GH peptides handle lean mass). Also complements fasting and HIIT training protocols.
What Is the Bottom Line on AOD-9604?
AOD-9604 is a Lipolytic peptide, GH fragment analog researched for fat loss, increased fat oxidation, improved body composition, joint health support, no IGF-1 elevation. Standard protocols use 250-1000 mcg daily once daily, ideally morning fasted for 12-24 weeks.
Source from COA-tested vendors. Read our beginner's guide for more, or use the dosing calculator to plan your protocol.
Complete Guide
AOD-9604: The Fat Loss Peptide Fragment
Related Reading
- AOD-9604 Dosage Guide
- AOD-9604 Benefits
- AOD-9604 Side Effects
- AOD-9604 Stacking Guide
- AOD-9604 Cycle Guide
- AOD-9604 Research
Research-Grade Sourcing
If you're going to research AOD-9604, source matters. These are the suppliers WolveStack has vetted for purity and third-party testing.
Frequently Asked Questions
What is AOD-9604?
AOD-9604 (Fragment 177-191 of Human Growth Hormone (modified)) is a Lipolytic peptide, GH fragment analog. Synthetic analog of human GH fragment 177-191, engineered to selectively activate lipolysis without systemic GH effects. It is researched for fat loss, increased fat oxidation, improved body composition, joint health support, no IGF-1 elevation.
What is the recommended AOD-9604 dosage?
Common dosages: 250-1000 mcg daily administered once daily, ideally morning fasted via subcutaneous injection. Cycle length: 12-24 weeks. Half-life: not established. Use our peptide calculator for exact reconstitution math.
What are the side effects of AOD-9604?
Well-tolerated across 900+ participants in clinical trials. Minimal adverse effects — potential mild headache, dizziness, or injection site reactions. One of the safest peptides in terms of documented human tolerability.
Is AOD-9604 safe?
AOD-9604 has shown a favorable safety profile in research. Not FDA-approved. Development discontinued 2007. Available as research chemical. All research should follow appropriate safety protocols.